Astronauts search for solutions to save a dying Earth by searching on Mars, only to have the mission go terribly awry.
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Dek, a decent but somewhat dull man, enjoys a happy existence with beloved girlfriend Shirley. They live together with her 12-year-old, Marlene: her daughter by the delinquent Jimmy, who flew the coop years ago and hasn’t been heard from since. Dek loves Shirley so much that he proposes to her on national television.
After a car crash sends repressed cartoonist Stu Miley (Fraser) into a coma, he and the mischievous Monkeybone, his hilariously horny alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu’s body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!